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Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin- coated pits, and altered endosomal sorting
The phorbol ester phorbol myristate acetate (PMA) induces a rapid downregulation of CD4 from the surface of T cells and lymphocytic cell lines, as well as from CD4-transfected nonlymphoid cells. Here we have studied the mechanisms of this phorbol ester-induced CD4 modulation. Using HeLa-CD4 or NIH-3...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1993
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191214/ https://www.ncbi.nlm.nih.gov/pubmed/8376930 |