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Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
The immune system of aged individuals often produces antibodies that have lower affinity and are less protective than antibodies from young individuals. Recent studies in mice suggested that antibodies produced by old individuals may be encoded by distinct immunoglobulin (Ig) genes and that the soma...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1996
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192365/ https://www.ncbi.nlm.nih.gov/pubmed/8642299 |