Intracellular Aggregation of Polypeptides with Expanded Polyglutamine Domain Is Stimulated by Stress-Activated Kinase Mekk1

Abnormal proteins, which escape chaperone-mediated refolding or proteasome-dependent degradation, aggregate and form inclusion bodies (IBs). In several neurodegenerative diseases, such IBs can be formed by proteins with expanded polyglutamine (polyQ) domains (e.g., huntingtin). This work studies the...

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Detalles Bibliográficos
Autores principales: Meriin, Anatoli B., Mabuchi, Katsuhide, Gabai, Vladimir L., Yaglom, Julia A., Kazantsev, Alex, Sherman, Michael Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192371/
https://www.ncbi.nlm.nih.gov/pubmed/11352944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192371/
https://www.ncbi.nlm.nih.gov/pubmed/11352944

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