Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels
Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K(+) channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fu...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192379/ https://www.ncbi.nlm.nih.gov/pubmed/11352930 |
Sumario: | Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K(+) channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca(2+) can enter myoblasts and thereby trigger fusion via a window current through α1H T channels. |
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