Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels

Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K(+) channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fu...

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Detalles Bibliográficos
Autores principales: Fischer-Lougheed, Jacqueline, Liu, Jian-Hui, Espinos, Estelle, Mordasini, David, Bader, Charles R., Belin, Dominique, Bernheim, Laurent
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192379/
https://www.ncbi.nlm.nih.gov/pubmed/11352930
Descripción
Sumario:Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K(+) channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca(2+) can enter myoblasts and thereby trigger fusion via a window current through α1H T channels.