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Cure of Progressive Murine Leishmaniasis: Interleukin 4 Dominance Is Abolished by Transient CD4(+) T Cell Depletion and T Helper Cell Type 1–selective Cytokine Therapy
Progressive infection with Leishmania major in susceptible BALB/c mice is mediated by interleukin (IL)-4–producing T helper cell type 2 (Th2) CD4(+) T cells that, once established, become resistant to Th1-deviating therapies with recombinant (r)IL-12 and/or neutralizing anti–IL-4 antibodies. We soug...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1999
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192969/ https://www.ncbi.nlm.nih.gov/pubmed/10377185 |