Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

CD22 is a B cell–specific transmembrane glycoprotein that acts to dampen signals generated through the B cell antigen receptor (BCR): B cells from CD22-deficient mice give increased Ca(2+) fluxes on BCR ligation. Here we show that this B cell hyperresponsiveness correlates with the development of au...

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Detalles Bibliográficos
Autores principales: O'Keefe, Theresa L., Williams, Gareth T., Batista, Facundo D., Neuberger, Michael S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193034/
https://www.ncbi.nlm.nih.gov/pubmed/10209047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193034/
https://www.ncbi.nlm.nih.gov/pubmed/10209047

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