A Targeted Deletion of a Region Upstream from the J(κ )Cluster Impairs κ Chain Rearrangement In Cis in Mice and in the 103/bcl2 Cell Line

We have shown previously that a mutation of the KI-KII site immediately 5′ to J(κ1) on the mouse immunoglobulin light chain κ locus reduces the rearrangement level in cis, although it does not affect transcription. Here we deleted by homologous recombination in mouse embryonic stem cells a 4-kb DNA...

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Detalles Bibliográficos
Autores principales: Cocea, Laurentiu, De Smet, Annie, Saghatchian, Mahasti, Fillatreau, Simon, Ferradini, Laurent, Schurmans, Stéphane, Weill, Jean-Claude, Reynaud, Claude-Agnès
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193061/
https://www.ncbi.nlm.nih.gov/pubmed/10224284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193061/
https://www.ncbi.nlm.nih.gov/pubmed/10224284

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