Cargando…
A Targeted Deletion of a Region Upstream from the J(κ )Cluster Impairs κ Chain Rearrangement In Cis in Mice and in the 103/bcl2 Cell Line
We have shown previously that a mutation of the KI-KII site immediately 5′ to J(κ1) on the mouse immunoglobulin light chain κ locus reduces the rearrangement level in cis, although it does not affect transcription. Here we deleted by homologous recombination in mouse embryonic stem cells a 4-kb DNA...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1999
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193061/ https://www.ncbi.nlm.nih.gov/pubmed/10224284 |