Secondary Rearrangements and Hypermutation Generate Sufficient B Cell Diversity to Mount Protective Antiviral Immunoglobulin Responses

Variable (V) region gene replacement was recently implicated in B cell repertoire diversification, but the contribution of this mechanism to antibody responses is still unknown. To investigate the role of V gene replacements in the generation of antigen-specific antibodies, we analyzed antiviral imm...

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Detalles Bibliográficos
Autores principales: López-Macías, Constantino, Kalinke, Ulrich, Cascalho, Marilia, Wabl, Matthias, Hengartner, Hans, Zinkernagel, Rolf M., Lamarre, Alain
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193076/
https://www.ncbi.nlm.nih.gov/pubmed/10359583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193076/
https://www.ncbi.nlm.nih.gov/pubmed/10359583

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