Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-X(L)

Bcr-Abl–expressing leukemic cells are highly resistant to apoptosis induced by chemotherapeutic drugs. Although a number of signaling molecules have been shown to be activated by the Bcr-Abl kinase, the antiapoptotic pathway triggered by this oncogene has not been elucidated. Here, we show that the...

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Detalles Bibliográficos
Autores principales: Horita, Machiko, Andreu, Enrique Jose, Benito, Adalberto, Arbona, Cristina, Sanz, Cristina, Benet, Isana, Prosper, Felipe, Fernandez-Luna, Jose Luis
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193112/
https://www.ncbi.nlm.nih.gov/pubmed/10727459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193112/
https://www.ncbi.nlm.nih.gov/pubmed/10727459

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