Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-X(L) Levels in Vivo

The serine/threonine kinase protein kinase B (PKB)/Akt mediates cell survival in a variety of systems. We have generated transgenic mice expressing a constitutively active form of PKB (gag-PKB) to examine the effects of PKB activity on T lymphocyte survival. Thymocytes and mature T cells overexpress...

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Detalles Bibliográficos
Autores principales: Jones, Russell G., Parsons, Michael, Bonnard, Madeleine, Chan, Vera S.F., Yeh, Wen-Chen, Woodgett, James R., Ohashi, Pamela S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193154/
https://www.ncbi.nlm.nih.gov/pubmed/10811865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193154/
https://www.ncbi.nlm.nih.gov/pubmed/10811865

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