Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement

Mutations in the gene encoding Bruton's tyrosine kinase (btk) cause the B cell deficiency diseases X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. In vivo and in vitro studies indicate that the BTK protein is essential for B cell survival, cell cycle pro...

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Detalles Bibliográficos
Autores principales: Petro, James B., Rahman, S.M. Jamshedur, Ballard, Dean W., Khan, Wasif N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193161/
https://www.ncbi.nlm.nih.gov/pubmed/10811867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193161/
https://www.ncbi.nlm.nih.gov/pubmed/10811867

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