Expression of Bcl-X(L) Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

Lymphocytes deficient in the T cell costimulatory molecule CD28 exhibit defects in cell survival, clonal expansion, and differentiation into effector cells. It is known that CD28-mediated signaling results in the upregulation of the Bcl family member Bcl-X(L). To investigate the role that Bcl-X(L) p...

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Detalles Bibliográficos
Autores principales: Dahl, A. Maria, Klein, Christoph, Andres, Pietro G., London, Cheryl A., Lodge, Michael P., Mulligan, Richard C., Abbas, Abul K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193206/
https://www.ncbi.nlm.nih.gov/pubmed/10859328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193206/
https://www.ncbi.nlm.nih.gov/pubmed/10859328

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