Alteration at a Single Amino Acid Residue in the T Cell Receptor α Chain Complementarity Determining Region 2 Changes the Differentiation of Naive Cd4 T Cells in Response to Antigen from T Helper Cell Type 1 (Th1) to Th2

To study whether changes in the structure of a T cell receptor (TCR) at a single peptide-contacting residue could affect T cell priming with antigenic peptide, we made transgenic mice with a point mutation in the TCR α chain of the D10.G4.1 (D10) TCR and bred them to D10 β chain transgenic mice. The...

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Detalles Bibliográficos
Autores principales: Blander, J. Magarian, Sant'Angelo, Derek B., Bottomly, Kim, Janeway, Charles A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193209/
https://www.ncbi.nlm.nih.gov/pubmed/10859331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193209/
https://www.ncbi.nlm.nih.gov/pubmed/10859331

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