Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells

Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1–mediated transcriptional regulation of IFN-inducible genes. IRF-1(−/)− mice exhibit defective T helper type 1 (Th1) cell differentiation. We have used experimental leishmaniasis to show that, like IRF-1(−/)...

Descripción completa

Detalles Bibliográficos
Autores principales: Lohoff, Michael, Duncan, Gordon S., Ferrick, David, Mittrücker, Hans-Willi, Bischof, Susi, Prechtl, Stefan, Röllinghoff, Martin, Schmitt, Edgar, Pahl, Andreas, Mak, Tak W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193225/
https://www.ncbi.nlm.nih.gov/pubmed/10934221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193225/
https://www.ncbi.nlm.nih.gov/pubmed/10934221

Ejemplares similares