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Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells

Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1–mediated transcriptional regulation of IFN-inducible genes. IRF-1(−/)− mice exhibit defective T helper type 1 (Th1) cell differentiation. We have used experimental leishmaniasis to show that, like IRF-1(−/)...

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Detalles Bibliográficos
Autores principales:	Lohoff, Michael, Duncan, Gordon S., Ferrick, David, Mittrücker, Hans-Willi, Bischof, Susi, Prechtl, Stefan, Röllinghoff, Martin, Schmitt, Edgar, Pahl, Andreas, Mak, Tak W.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2000
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193225/ https://www.ncbi.nlm.nih.gov/pubmed/10934221

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