Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1): Evidence for an IL-12Rβ1–Independent Pathway of IL-12 Responsiveness in Human T Cells

Genetic lack of interleukin 12 receptor β1 (IL-12Rβ1) surface expression predisposes to severe infections by poorly pathogenic mycobacteria or Salmonella and causes strongly decreased, but not completely abrogated, interferon (IFN)-γ production. To study IL-12Rβ1–independent residual IFN-γ productio...

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Detalles Bibliográficos
Autores principales: Verhagen, Claudia E., de Boer, Tjitske, Smits, Hermelijn H., Verreck, Frank A.W., Wierenga, Eddy A., Kurimoto, M., Lammas, D. Anthony, Kumararatne, Dinakanthe S., Sanal, Ozden, Kroon, Frank P., van Dissel, Jaap T., Sinigaglia, Francesco, Ottenhoff, Tom H.M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193232/
https://www.ncbi.nlm.nih.gov/pubmed/10952721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193232/
https://www.ncbi.nlm.nih.gov/pubmed/10952721

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