Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

Immature CD4(+)CD8(+) thymocytes rearrange their T cell receptor (TCR)-α gene locus to generate clonotypic α/β TCR, after which a few cells expressing selectable TCR are signaled to further differentiate into mature T cells. Because of requirements for self-tolerance, immature CD4(+)CD8(+) thymocyte...

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Detalles Bibliográficos
Autores principales: Bhandoola, Avinash, Dolnick, Benjamin, Fayad, Nihal, Nussenzweig, Andre, Singer, Alfred
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193292/
https://www.ncbi.nlm.nih.gov/pubmed/10993919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193292/
https://www.ncbi.nlm.nih.gov/pubmed/10993919

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