Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune features. We report here that the ligand of PD-1 (PD-L1) is a member of the B7 gene family. Engageme...

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Detalles Bibliográficos
Autores principales: Freeman, Gordon J., Long, Andrew J., Iwai, Yoshiko, Bourque, Karen, Chernova, Tatyana, Nishimura, Hiroyuki, Fitz, Lori J., Malenkovich, Nelly, Okazaki, Taku, Byrne, Michael C., Horton, Heidi F., Fouser, Lynette, Carter, Laura, Ling, Vincent, Bowman, Michael R., Carreno, Beatriz M., Collins, Mary, Wood, Clive R., Honjo, Tasuku
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193311/
https://www.ncbi.nlm.nih.gov/pubmed/11015443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193311/
https://www.ncbi.nlm.nih.gov/pubmed/11015443

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