Complement C4 Inhibits Systemic Autoimmunity through a Mechanism Independent of Complement Receptors Cr1 and Cr2

The complement system enhances antibody responses to T-dependent antigens, but paradoxically, deficiencies in C1 and C4 are strongly linked to autoantibody production in humans. In mice, disruption of the C1qa gene also results in spontaneous autoimmunity. Moreover, deficiencies in C4 or complement...

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Detalles Bibliográficos
Autores principales: Chen, Zhibin, Koralov, Sergei B., Kelsoe, Garnett
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193358/
https://www.ncbi.nlm.nih.gov/pubmed/11067882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193358/
https://www.ncbi.nlm.nih.gov/pubmed/11067882

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