The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV: The Arg142gln Mutation Impairs Binding to Cd26 but Does Not Cause Immune Deficiency

Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory function of CD26 on T lymphocytes. Absence of ADA–CD26 binding...

Descripción completa

Detalles Bibliográficos
Autores principales: Richard, Eva, Arredondo-Vega, Francisco X., Santisteban, Ines, Kelly, Susan J., Patel, Dhavalkumar D., Hershfield, Michael S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193361/
https://www.ncbi.nlm.nih.gov/pubmed/11067872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193361/
https://www.ncbi.nlm.nih.gov/pubmed/11067872

Ejemplares similares