Cargando…

The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV: The Arg142gln Mutation Impairs Binding to Cd26 but Does Not Cause Immune Deficiency

Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory function of CD26 on T lymphocytes. Absence of ADA–CD26 binding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richard, Eva, Arredondo-Vega, Francisco X., Santisteban, Ines, Kelly, Susan J., Patel, Dhavalkumar D., Hershfield, Michael S.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2000
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193361/ https://www.ncbi.nlm.nih.gov/pubmed/11067872

Ejemplares similares

Dipeptidyl peptidase-4 (DPP-4; CD26)
Publicado: (2013)

CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions
por: Pan, Kelsey, et al.
Publicado: (2021)

Regulation of Chemokine Activity – A Focus on the Role of Dipeptidyl Peptidase IV/CD26
por: Metzemaekers, Mieke, et al.
Publicado: (2016)

Molecular Evidence of Adenosine Deaminase Linking Adenosine A(2A) Receptor and CD26 Proteins
por: Moreno, Estefanía, et al.
Publicado: (2018)

Immunoelectron microscopic single and double labelling of aminopeptidase N (CD 13) and dipeptidyl peptidase IV (CD 26)
por: Stange, Thoralf, et al.
Publicado: (1996)

CD26/dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected Female sex workers
por: Songok, Elijah M, et al.
Publicado: (2010)

Cd26/Dipeptidyl Peptidase IV in Context: The Different Roles of a Multifunctional Ectoenzyme in Malignant Transformation
por: Iwata, Satoshi, et al.
Publicado: (1999)

Mapping Salivary Proteases in Sjögren’s Syndrome Patients Reveals Overexpression of Dipeptidyl Peptidase-4/CD26
por: Garreto, Laís, et al.
Publicado: (2021)

Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores
por: Soslow, Jonathan H., et al.
Publicado: (2017)

Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26
por: Fletcher, Mary A., et al.
Publicado: (2010)

Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target
por: Doonan, Bently P., et al.
Publicado: (2017)

CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors
por: Sato, K, et al.
Publicado: (2003)

Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G(2)/M arrest induced by topoisomerase II inhibitors
por: Aytac, U, et al.
Publicado: (2003)

Soluble CD26/Dipeptidyl Peptidase IV Enhances the Transcription of IL-6 and TNF-α in THP-1 Cells and Monocytes
por: Ikeda, Tetsurou, et al.
Publicado: (2013)

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma
por: Mandapathil, Magis, et al.
Publicado: (2012)

Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning
por: Schwaiger, Elisabeth, et al.
Publicado: (2012)

Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling
por: Metzemaekers, Mieke, et al.
Publicado: (2017)

Expression patterns of the ectopeptidases aminopeptidase N/CD13 and dipeptidyl peptidase IVICD26: immunoultrastructural topographic localization on different types of cultured cells
por: Stange, Thoralf, et al.
Publicado: (1998)

Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage
por: Oravecz, Tamas, et al.
Publicado: (1997)

Effect of narrowband ultraviolet B therapy on serum levels of CD26/dipeptidyl-peptidase IV and truncated forms of substance P in psoriasis patients with pruritus
por: Kongthong, S, et al.
Publicado: (2019)

Conformational Changes of Congenital FVII Variants with Defective Binding to Tissue Factor ARG304GLN (FVII Padua), ARG 304TRP (FVII Nagoya) and ARG79GLN (FVII Shinjo or Tondabayashi)
por: Cristiani, Andrea, et al.
Publicado: (2013)

Biochemical characterization of adenosine deaminase (CD26; EC 3.5.4.4) activity in human lymphocyte-rich peripheral blood mononuclear cells
por: Costa, L.R., et al.
Publicado: (2021)

An angiotensin-converting enzyme inhibitor modulates stromal-derived factor-1 through CD26/dipeptidyl peptidase IV to inhibit laser-induced choroidal neovascularization
por: Li, Hong, et al.
Publicado: (2013)

Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III
por: Matić, Antonia, et al.
Publicado: (2023)

Serum Levels of Soluble CD26/Dipeptidyl Peptidase-IV in Type 2 Diabetes Mellitus and Its Association with Metabolic Syndrome and Therapy with Antidiabetic Agents in Malaysian Subjects
por: Ahmed, Radwan H., et al.
Publicado: (2015)

CD26 and Cancer
por: Cordero, Oscar J.
Publicado: (2022)

New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors
por: Cui, Chenkai, et al.
Publicado: (2022)

The deficiency of adenosine deaminase type 2-results of therapeutic intervention
por: Ombrello, A, et al.
Publicado: (2015)

The influence of CD26(+) and CD26(−) fibroblasts on the regeneration of human dermo-epidermal skin substitutes
por: Michalak-Micka, Katarzyna, et al.
Publicado: (2022)

Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency
por: Komarow, Hirsh D., et al.
Publicado: (2015)

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis
por: Vieira, Cátia, et al.
Publicado: (2014)

CD26 Expression on T Helper Populations and sCD26 Serum Levels in Patients with Rheumatoid Arthritis
por: Cordero, Oscar J., et al.
Publicado: (2015)

Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over
por: Kling, Lovis, et al.
Publicado: (2017)

CD26-Related Serum Biomarkers: sCD26 Protein, DPP4 Activity, and Anti-CD26 Isotype Levels in a Colorectal Cancer-Screening Context
por: De Chiara, Loretta, et al.
Publicado: (2020)

Correction: CD26 Expression on T Helper Populations and sCD26 Serum Levels in Patients with Rheumatoid Arthritis
por: Cordero, Oscar J., et al.
Publicado: (2015)

CD9 Negatively Regulates CD26 Expression and Inhibits CD26-Mediated Enhancement of Invasive Potential of Malignant Mesothelioma Cells
por: Okamoto, Toshihiro, et al.
Publicado: (2014)

Distinctive CD26 Expression on CD4 T-Cell Subsets
por: Cordero, Oscar J., et al.
Publicado: (2021)

Serum and Adipose Dipeptidyl Peptidase 4 in Cardiovascular Surgery Patients: Influence of Dipeptidyl Peptidase 4 Inhibitors
por: Shibasaki, Ikuko, et al.
Publicado: (2022)

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
por: Lu, Guangwen, et al.
Publicado: (2013)

Evolutionary Analysis of Dipeptidyl Peptidase I
por: Varda, Nina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e0lehijtbr97pp19s229q5v63i