T Cell Recognition of the Dominant I-A(k)–Restricted Hen Egg Lysozyme Epitope: Critical Role for Asparagine Deamidation

Type-B T cells raised against the immunodominant peptide in hen egg lysozyme (HEL(48–62)) do not respond to whole lysozyme, and this has been thought to indicate that peptide can bind to l-A(k) in different conformations. Here we demonstrate that such T cells recognize a deamidated form of the HEL p...

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Detalles Bibliográficos
Autores principales: McAdam, Stephen N., Fleckenstein, Burkhard, Rasmussen, Ingunn B., Schmid, Dietmar G., Sandlie, Inger, Bogen, Bjarne, Viner, Nicholas J., Sollid, Ludvig M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193382/
https://www.ncbi.nlm.nih.gov/pubmed/11390431

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