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Insertion of Phosphoglycerine Kinase (Pgk)-Neo 5′ of Jλ1 Dramatically Enhances Vjλ1 Rearrangement
Gene-targeted mice were generated with a loxP-neomycin resistance gene (neo(r)) cassette inserted upstream of the Jλ1 region and replacement of the glycine 154 codon in the Cλ1 gene with a serine codon. This insertion dramatically increases Vλ1-Jλ1 recombination. Jλ1 germline transcription levels in...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193413/ https://www.ncbi.nlm.nih.gov/pubmed/11257137 |