The Adenylate Cyclase Toxin of Bordetella pertussis Binds to Target Cells via the α(M)β(2) Integrin (Cd11b/Cd18)

The adenylate cyclase toxin (CyaA) of Bordetella pertussis is a major virulence factor required for the early phases of lung colonization. It can invade eukaryotic cells where, upon activation by endogenous calmodulin, it catalyzes the formation of unregulated cAMP levels. CyaA intoxication leads to...

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Detalles Bibliográficos
Autores principales: Guermonprez, Pierre, Khelef, Nadia, Blouin, Eric, Rieu, Philippe, Ricciardi-Castagnoli, Paola, Guiso, Nicole, Ladant, Daniel, Leclerc, Claude
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193436/
https://www.ncbi.nlm.nih.gov/pubmed/11342588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193436/
https://www.ncbi.nlm.nih.gov/pubmed/11342588

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