Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13

Expulsion of the gastrointestinal nematode Trichuris muris is mediated by a T helper (Th) 2 type response involving interleukin (IL)-4 and IL-13. Here we show that Th1 response–associated susceptibility involves prior activation of IL-18 and caspase-1 followed by IL-12 and interferon (IFN)-γ in the...

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Detalles Bibliográficos
Autores principales: Helmby, Helena, Takeda, Kiyoshi, Akira, Shizuo, Grencis, Richard K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193471/
https://www.ncbi.nlm.nih.gov/pubmed/11489954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193471/
https://www.ncbi.nlm.nih.gov/pubmed/11489954

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