Sialylated O-Glycans and Sulfated Tyrosines in the NH(2)-Terminal Domain of CC Chemokine Receptor 5 Contribute to High Affinity Binding of Chemokines

The chemokine receptor CCR5 plays an important role in leukocyte chemotaxis and activation, and also acts as a coreceptor for human and simian immunodeficiency viruses (HIV-1, HIV-2, and SIV). We provide evidence that CCR5 is O-glycosylated on serine 6 in the NH(2) terminus. The O-linked glycans, pa...

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Detalles Bibliográficos
Autores principales: Bannert, Norbert, Craig, Stewart, Farzan, Michael, Sogah, Dodzie, Santo, Niki Villanueva, Choe, Hyeryun, Sodroski, Joseph
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193526/
https://www.ncbi.nlm.nih.gov/pubmed/11733580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193526/
https://www.ncbi.nlm.nih.gov/pubmed/11733580

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