CD8(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function

CD8(+) T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We have made a T cell receptor (TCR) transgenic mouse specific for a tumor antigen and crossed TCR-TG mice to transgenic mice expressing the tumor an...

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Detalles Bibliográficos
Autores principales: Öhlén, Claes, Kalos, Michael, Cheng, Laurence E., Shur, Aaron C., Hong, Doley J., Carson, Bryan D., Kokot, Niels C.T., Lerner, Cara G., Sather, Blythe D., Huseby, Eric S., Greenberg, Philip D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193546/
https://www.ncbi.nlm.nih.gov/pubmed/12045239
http://dx.doi.org/10.1084/jem.20011063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193546/
https://www.ncbi.nlm.nih.gov/pubmed/12045239
http://dx.doi.org/10.1084/jem.20011063

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