Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice

The adaptor protein Lnk, and the closely related proteins APS and SH2B, form a subfamily of SH2 domain-containing proteins implicated in growth factor, cytokine, and immunoreceptor signaling. To elucidate the physiological function of Lnk, we derived Lnk-deficient mice. Lnk (−/−) mice are viable, bu...

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Detalles Bibliográficos
Autores principales: Velazquez, Laura, Cheng, Alec M., Fleming, Heather E., Furlonger, Caren, Vesely, Shirly, Bernstein, Alan, Paige, Christopher J., Pawson, Tony
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193556/
https://www.ncbi.nlm.nih.gov/pubmed/12070287
http://dx.doi.org/10.1084/jem.20011883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193556/
https://www.ncbi.nlm.nih.gov/pubmed/12070287
http://dx.doi.org/10.1084/jem.20011883

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