Restrictions Limiting the Generation of DNA Double Strand Breaks during Chromosomal V(D)J Recombination

Antigen receptor loci are composed of numerous variable (V), diversity (D), and joining (J) gene segments, each flanked by recombination signal sequences (RSSs). The V(D)J recombination reaction proceeds through RSS recognition and DNA cleavage steps making it possible for multiple DNA double strand...

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Detalles Bibliográficos
Autores principales: Tillman, Robert E., Wooley, Andrea L., Hughes, Maureen M., Wehrly, Tara D., Swat, Wojciech, Sleckman, Barry P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193590/
https://www.ncbi.nlm.nih.gov/pubmed/11828005
http://dx.doi.org/10.1084/jem.20011803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193590/
https://www.ncbi.nlm.nih.gov/pubmed/11828005
http://dx.doi.org/10.1084/jem.20011803

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