Cargando…

Complement C3 Activation Is Required for Antiphospholipid Antibody-induced Fetal Loss

The antiphospholipid syndrome (APS) is characterized by recurrent fetal loss, vascular thrombosis, and thrombocytopenia occurring in the presence of antiphospholipid (aPL) antibodies. The pathogenesis of fetal loss and tissue injury in APS is incompletely understood, but is thought to involve platel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holers, V. Michael, Girardi, Guillermina, Mo, Lian, Guthridge, Joel M., Molina, Hector, Pierangeli, Silvia S., Espinola, Ricardo, Xiaowei, Liu E., Mao, Dailing, Vialpando, Christopher G., Salmon, Jane E.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193604/ https://www.ncbi.nlm.nih.gov/pubmed/11805148 http://dx.doi.org/10.1084/jem.200116116

Ejemplares similares

Antiphospholipid antibodies harness innate effectors, neutrophils and an alternative pathway of complement, to induce fetal damage
por: Salmon, J, et al.
Publicado: (2003)

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
por: Girardi, Guillermina, et al.
Publicado: (2006)

The Role of Complement Inhibition in Thrombotic Angiopathies and Antiphospholipid Syndrome
por: Erkan, Doruk, et al.
Publicado: (2016)

Inhibition of complement activation: a novel mechanism for the protective effects of heparin in antiphospholipid antibody-induced pregnancy loss
por: Girardi, G, et al.
Publicado: (2004)

Pathophysiology of the antiphospholipid antibody syndrome
por: Willis, Rohan, et al.
Publicado: (2011)

Complement in the Pathophysiology of the Antiphospholipid Syndrome
por: Chaturvedi, Shruti, et al.
Publicado: (2019)

Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
por: Tedesco, Francesco, et al.
Publicado: (2018)

Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
por: Barratt-Due, Andreas, et al.
Publicado: (2016)

Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond
por: Girardi, Guillermina, et al.
Publicado: (2020)

Complement in the Initiation and Evolution of Rheumatoid Arthritis
por: Holers, V. Michael, et al.
Publicado: (2018)

Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
por: Sood, Rashmi, et al.
Publicado: (2007)

Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)
por: Savelli, Stephanie L., et al.
Publicado: (2019)

Complement C5a is present in CSF of human newborns and is elevated in association with preterm birth
por: Pataky, Rozalia, et al.
Publicado: (2017)

Recurrent Fetal Loss and Antiphospholipid Antibodies: Clinical and Therapeutic Aspects
por: Blétry, O., et al.
Publicado: (1997)

Fetal Intraventricular Hemorrhage Due to Antiphospholipid Syndrome: A Case Report
por: Bouw, M. C., et al.
Publicado: (2021)

Platelets and the Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus or Antiphospholipid Syndrome
por: Vils, Signe Risbøl, et al.
Publicado: (2023)

16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends
por: Cohen, Hannah, et al.
Publicado: (2020)

Low Preconception Complement Levels Are Associated with Adverse Pregnancy Outcomes in a Multicenter Study of 260 Pregnancies in 197 Women with Antiphospholipid Syndrome or Carriers of Antiphospholipid Antibodies
por: Nalli, Cecilia, et al.
Publicado: (2021)

Natural antibodies and antiphospholipid antibodies bind to injured tissues, activate complement and cause tissue damage
por: Tsokos, G, et al.
Publicado: (2003)

Complement and autoimmunity: new insights into old questions
por: Holers, VM, et al.
Publicado: (2004)

Intrauterine fetal deaths related to antiphospholipid syndrome: a descriptive study of 65 women
por: Belhocine, Mériem, et al.
Publicado: (2018)

Antiphospholipid Antibodies Increase the Risk of Fetal Growth Restriction: A Systematic Meta-Analysis
por: Xu, Jinfeng, et al.
Publicado: (2022)

A Potential New Mouse Model of Axial Spondyloarthritis Involving the Complement System
por: Holers, V. Michael, et al.
Publicado: (2021)

Blood Cell-Bound C4d as a Marker of Complement Activation in Patients With the Antiphospholipid Syndrome
por: Lonati, Paola Adele, et al.
Publicado: (2019)

Complement-Mediated Thrombotic Microangiopathy in a Patient With Antiphospholipid Syndrome and Anti-glomerular Basement Membrane Antibodies
por: Gallant, Tara L, et al.
Publicado: (2023)

Antiphospholipid antibodies and thrombosis: pathogenesis of antiphospholipid syndrome
por: Koike, T
Publicado: (2003)

Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome
por: Devreese, Katrien M.J., et al.
Publicado: (2021)

Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D
por: Holers, V. Michael, et al.
Publicado: (2020)

The Effect of Rituximab on Antiphospholipid Titers in Patients with Antiphospholipid Syndrome
por: Youkhana, Kimberley, et al.
Publicado: (2023)

CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome
por: Sarmiento, Elizabeth, et al.
Publicado: (2014)

Oxidation of β2-glycoprotein I associates with IgG antibodies to domain I in patients with antiphospholipid syndrome
por: Raimondo, Maria Gabriella, et al.
Publicado: (2017)

Antiphospholipid Antibodies Attenuate Endothelial Repair and Promote Neointima Formation in Mice
por: Ulrich, Victoria, et al.
Publicado: (2014)

Is It Antiphospholipid Syndrome?
por: Ditto, Maria Chiara, et al.
Publicado: (2010)

Antiphospholipid syndrome
por: Espinosa, Gerard, et al.
Publicado: (2008)

The Antiphospholipid Syndrome
por: Hughes, Graham R V, et al.
Publicado: (1994)

Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
por: Levy, Roger A., et al.
Publicado: (2015)

Management of Women with Antiphospholipid Antibodies or Antiphospholipid Syndrome during Pregnancy
por: Lee, Eunyoung Emily, et al.
Publicado: (2021)

Antiphospholipid antibodies among pregnant women with recurrent fetal wastage in a tertiary hospital in Northern Nigeria
por: Abdullahi, Zubaida Garba, et al.
Publicado: (2016)

IgA Antiphospholipid Antibodies in Antiphospholipid Syndrome and Systemic Lupus Erythematosus
por: Reshetnyak, Tatiana, et al.
Publicado: (2022)

Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added
por: Liu, Xiangjun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s200gu6s2rtuebearhqkcq9r72