A Role for Neutral Sphingomyelinase-mediated Ceramide Production in T Cell Receptor–induced Apoptosis and Mitogen-activated Protein Kinase–mediated Signal Transduction

Studying apoptosis induced by T cell receptor (TCR) cross-linking in the T cell hybridoma, 3DO, we found both neutral sphingomyelinase activation and production of ceramide upon receptor engagement. Pharmacological inhibition of ceramide production by the fungal toxin, fumonisin B1, impaired TCR-ind...

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Detalles Bibliográficos
Autores principales: Tonnetti, Laura, Verí, Maria-Concetta, Bonvini, Ezio, D'Adamio, Luciano
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193632/
https://www.ncbi.nlm.nih.gov/pubmed/10330437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193632/
https://www.ncbi.nlm.nih.gov/pubmed/10330437

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