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A Human Immunoglobulin λ Locus Is Similarly Well Expressed in Mice and Humans

Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) λ light (L) chain locus in germline configuration were created. The introduced translocus on a yeast artificial chromosome (YAC) accommodates the most proximal Igλ variable region (V) gene cluster, including 15 Vλ genes that c...

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Detalles Bibliográficos
Autores principales: Popov, Andrei V., Zou, Xiangang, Xian, Jian, Nicholson, Ian C., Brüggemann, Marianne
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193639/
https://www.ncbi.nlm.nih.gov/pubmed/10330440