Germinal Center B Cells Regulate Their Capability to Present Antigen by Modulation of HLA-DO

Peptide acquisition by MHC class II molecules is catalyzed by HLA-DM (DM). In B cells, HLA-DO (DO) inhibits or modifies the peptide exchange activity of DM. We show here that DO protein levels are modulated during B cell differentiation. Remarkably, germinal center (GC) B cells, which have low level...

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Detalles Bibliográficos
Autores principales: Glazier, Kim S., Hake, Sandra B., Tobin, Helen M., Chadburn, Amy, Schattner, Elaine J., Denzin, Lisa K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193692/
https://www.ncbi.nlm.nih.gov/pubmed/11956297
http://dx.doi.org/10.1084/jem.20012059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193692/
https://www.ncbi.nlm.nih.gov/pubmed/11956297
http://dx.doi.org/10.1084/jem.20012059

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