Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

Vav1 is a signal transducing protein required for T cell receptor (TCR) signals that drive positive and negative selection in the thymus. Furthermore, Vav1-deficient thymocytes show greatly reduced TCR-induced intracellular calcium flux. Using a novel genetic system which allows the study of signali...

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Detalles Bibliográficos
Autores principales: Reynolds, Lucinda F., Smyth, Lesley A., Norton, Trisha, Freshney, Norman, Downward, Julian, Kioussis, Dimitris, Tybulewicz, Victor L.J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193701/
https://www.ncbi.nlm.nih.gov/pubmed/11994416
http://dx.doi.org/10.1084/jem.20011663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193701/
https://www.ncbi.nlm.nih.gov/pubmed/11994416
http://dx.doi.org/10.1084/jem.20011663

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