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The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process
Activation of B cells by antigen fuels two distinct molecular modifications of immunoglobulin (Ig) genes. Class-switch recombination (CSR) replaces the Igμ heavy chain constant region with a downstream constant region gene, thereby altering the effector function of the resulting antibodies. Somatic...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193708/ https://www.ncbi.nlm.nih.gov/pubmed/11994424 http://dx.doi.org/10.1084/jem.20011858 |