Competition Between Two MHC Binding Registers in a Single Peptide Processed from Myelin Basic Protein Influences Tolerance and Susceptibility to Autoimmunity

Experimental allergic encephalomyelitis (EAE) is an animal model for multiple sclerosis induced by stimulating myelin basic protein (MBP)-specific T cells. The MBP-specific repertoire in B10.PL mice is shaped by tolerance mechanisms that eliminate MBP121–150–specific T cells. In contrast, MBPAc1–11–...

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Detalles Bibliográficos
Autores principales: Seamons, Audrey, Sutton, Jennifer, Bai, Dina, Baird, Emily, Bonn, Nena, Kafsack, Björn F.C., Shabanowitz, Jeffrey, Hunt, Donald F., Beeson, Craig, Goverman, Joan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193784/
https://www.ncbi.nlm.nih.gov/pubmed/12756272
http://dx.doi.org/10.1084/jem.20022226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193784/
https://www.ncbi.nlm.nih.gov/pubmed/12756272
http://dx.doi.org/10.1084/jem.20022226

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