Cargando…

Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics: ciprofloxacin (CPX) or norfloxacin (NFX). CPX or NFX plus UV light (N...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boya, Patricia, Andreau, Karine, Poncet, Delphine, Zamzami, Naoufal, Perfettini, Jean-Luc, Metivier, Didier, Ojcius, David M., Jäättelä, Marja, Kroemer, Guido
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/ https://www.ncbi.nlm.nih.gov/pubmed/12756268 http://dx.doi.org/10.1084/jem.20021952

Ejemplares similares

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism
por: Mena, Salvador, et al.
Publicado: (2012)

Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells
por: Stahl-Meyer, Kamilla, et al.
Publicado: (2022)

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
por: Nylandsted, Jesper, et al.
Publicado: (2004)

Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2
por: Jacotot, Etienne, et al.
Publicado: (2001)

Lysosome-Targeted Biosensor for the Super-Resolution Imaging of Lysosome–Mitochondrion Interaction
por: Wang, Han, et al.
Publicado: (2022)

Ragulator—a multifaceted regulator of lysosomal signaling and trafficking
por: Colaço, Alexandria, et al.
Publicado: (2017)

Regulation of apoptosis-associated lysosomal membrane permeabilization
por: Johansson, Ann-Charlotte, et al.
Publicado: (2010)

Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization
por: Ziglari, Tahereh, et al.
Publicado: (2021)

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells
por: Beauvarlet, Jennifer, et al.
Publicado: (2020)

They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
por: Hämälistö, Saara, et al.
Publicado: (2021)

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors
por: Chen, Ran, et al.
Publicado: (2020)

Lysosomal Changes in Mitosis
por: Stahl-Meyer, Jonathan, et al.
Publicado: (2022)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
por: Halaby, Reginald
Publicado: (2021)

Mitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor: A Novel Target for Viral and Pharmacological Manipulation
por: Castedo, Maria, et al.
Publicado: (2002)

TFEB‐dependent lysosome biogenesis is required for senescence
por: Curnock, Rachel, et al.
Publicado: (2023)

Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons
por: YAN, MIN, et al.
Publicado: (2016)

Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization
por: Park, Sang-Hyun, et al.
Publicado: (2021)

Real-Time Monitoring of Lysosomal Membrane Permeabilization Using Acridine Orange
por: Eriksson, Ida, et al.
Publicado: (2023)

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy
por: Li, Youyou, et al.
Publicado: (2023)

Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
por: Perfettini, Jean-Luc, et al.
Publicado: (2005)

Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs
por: Persson, Hans L, et al.
Publicado: (2013)

PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization
por: Liu, Jiazhuo, et al.
Publicado: (2015)

Changes of lysosomal membrane permeabilization and lipid metabolism in sidt2 deficient mice
por: Meng, Yu, et al.
Publicado: (2018)

MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization
por: Banerjee, Sulagna, et al.
Publicado: (2012)

(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization
por: LeGendre, Onica, et al.
Publicado: (2015)

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
por: Goren, Limor, et al.
Publicado: (2019)

Lysosome-targeting agents in cancer therapy
por: Kroemer, Guido, et al.
Publicado: (2017)

DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4(+) T Cells Infected with HIV
por: Laforge, Mireille, et al.
Publicado: (2013)

The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation
por: Chen, Fang, et al.
Publicado: (2016)

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
por: Dyshlovoy, Sergey A., et al.
Publicado: (2015)

Suppressing UVRAG Induces Radiosensitivity by Triggering Lysosomal Membrane Permeabilization in Hypopharyngeal Squamous Cell Carcinoma
por: Wang, Jianwen, et al.
Publicado: (2020)

Disulfiram, a Ferroptosis Inducer, Triggers Lysosomal Membrane Permeabilization by Up-Regulating ROS in Glioblastoma
por: Qiu, Chen, et al.
Publicado: (2020)

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells
por: Cash, Timothy P., et al.
Publicado: (2020)

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
por: Zhang, Kevin R., et al.
Publicado: (2023)

Identification of Cytoskeleton-Associated Proteins Essential for Lysosomal Stability and Survival of Human Cancer Cells
por: Groth-Pedersen, Line, et al.
Publicado: (2012)

Is myelin a mitochondrion?
por: Harris, Julia J, et al.
Publicado: (2013)

Of mitochondrion and COVID-19
por: Alfarouk, Khalid Omer, et al.
Publicado: (2021)

Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release
por: Marques, C, et al.
Publicado: (2013)

ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells
por: Cai, Xianyi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_j1110uthgu1doeofkiqskf5f5d