Positive Selection of Anti–Thy-1 Autoreactive B-1 Cells and Natural Serum Autoantibody Production Independent from Bone Marrow B Cell Development

A natural serum autoantibody specific for the Thy-1 glycoprotein (anti–Thy-1 autoantibody [ATA]) is produced by B-1 cells that are positively selected by self-antigen. Here, using ATAμκ transgenic mice we show that cells with this B cell receptor are negatively selected during bone marrow (BM) devel...

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Detalles Bibliográficos
Autores principales: Hayakawa, Kyoko, Asano, Masanao, Shinton, Susan A., Gui, Ming, Wen, Li-Jun, Dashoff, Joni, Hardy, Richard R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193793/
https://www.ncbi.nlm.nih.gov/pubmed/12515816
http://dx.doi.org/10.1084/jem.20021459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193793/
https://www.ncbi.nlm.nih.gov/pubmed/12515816
http://dx.doi.org/10.1084/jem.20021459

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