Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells

T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands that activate TCR-γδ cells. In tumor cells, blockade of hydroxy-methylglutaryl-CoA reductase (HMGR), the rate limiting enzyme o...

Descripción completa

Detalles Bibliográficos
Autores principales: Gober, Hans-Jürgen, Kistowska, Magdalena, Angman, Lena, Jenö, Paul, Mori, Lucia, De Libero, Gennaro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193814/
https://www.ncbi.nlm.nih.gov/pubmed/12538656
http://dx.doi.org/10.1084/jem.20021500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193814/
https://www.ncbi.nlm.nih.gov/pubmed/12538656
http://dx.doi.org/10.1084/jem.20021500

Ejemplares similares