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Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8(+) T Cells
Activated insulin-specific CD8(+) T cells (IS-CD8(+) cells) home to the pancreas, destroy β cells, and cause rapid diabetes upon transfer into diabetes-prone NOD mice. Surprisingly, they also cause diabetes in mouse strains that are free of preexistent inflammation. Thus, we hypothesized that islet-...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193823/ https://www.ncbi.nlm.nih.gov/pubmed/12615905 http://dx.doi.org/10.1084/jem.20021378 |