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Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8(+) T Cells

Activated insulin-specific CD8(+) T cells (IS-CD8(+) cells) home to the pancreas, destroy β cells, and cause rapid diabetes upon transfer into diabetes-prone NOD mice. Surprisingly, they also cause diabetes in mouse strains that are free of preexistent inflammation. Thus, we hypothesized that islet-...

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Detalles Bibliográficos
Autores principales:	Savinov, Alexei Y., Wong, F. Susan, Stonebraker, Austin C., Chervonsky, Alexander V.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193823/ https://www.ncbi.nlm.nih.gov/pubmed/12615905 http://dx.doi.org/10.1084/jem.20021378

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