Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells

In developing lymphocytes, the recombination activating gene endonuclease cleaves DNA between V, D, or J coding and recombination signal (RS) sequences to form hairpin coding and blunt RS ends, which are fused to form coding and RS joins. Nonhomologous end joining (NHEJ) factors repair DNA double st...

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Detalles Bibliográficos
Autores principales: Rooney, Sean, Alt, Frederick W., Lombard, David, Whitlow, Scott, Eckersdorff, Mark, Fleming, James, Fugmann, Sebastian, Ferguson, David O., Schatz, David G., Sekiguchi, JoAnn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193825/
https://www.ncbi.nlm.nih.gov/pubmed/12615897
http://dx.doi.org/10.1084/jem.20021891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193825/
https://www.ncbi.nlm.nih.gov/pubmed/12615897
http://dx.doi.org/10.1084/jem.20021891

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