Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice

Indirect evidence suggests that type-I interferons (IFN-α/β) play a significant role in the pathogenesis of lupus. To directly examine the contribution of these pleiotropic molecules, we created congenic NZB mice lacking the α-chain of IFN-α/βR, the common receptor for the multiple IFN-α/β species....

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Detalles Bibliográficos
Autores principales: Santiago-Raber, Marie-Laure, Baccala, Roberto, Haraldsson, Katarina M., Choubey, Divaker, Stewart, Timothy A., Kono, Dwight H., Theofilopoulos, Argyrios N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193854/
https://www.ncbi.nlm.nih.gov/pubmed/12642605
http://dx.doi.org/10.1084/jem.20021996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193854/
https://www.ncbi.nlm.nih.gov/pubmed/12642605
http://dx.doi.org/10.1084/jem.20021996

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