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Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice
Indirect evidence suggests that type-I interferons (IFN-α/β) play a significant role in the pathogenesis of lupus. To directly examine the contribution of these pleiotropic molecules, we created congenic NZB mice lacking the α-chain of IFN-α/βR, the common receptor for the multiple IFN-α/β species....
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193854/ https://www.ncbi.nlm.nih.gov/pubmed/12642605 http://dx.doi.org/10.1084/jem.20021996 |