Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor β1 Deficiency: Medical and Immunological Implications

The clinical phenotype of interleukin 12 receptor β1 chain (IL-12Rβ1) deficiency and the function of human IL-12 in host defense remain largely unknown, due to the small number of patients reported. We now report 41 patients with complete IL-12Rβ1 deficiency from 17 countries. The only opportunistic...

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Detalles Bibliográficos
Autores principales: Fieschi, Claire, Dupuis, Stéphanie, Catherinot, Emilie, Feinberg, Jacqueline, Bustamante, Jacinta, Breiman, Adrien, Altare, Frédéric, Baretto, Richard, Le Deist, Françoise, Kayal, Samer, Koch, Hartmut, Richter, Darko, Brezina, Martin, Aksu, Guzide, Wood, Phil, Al-Jumaah, Suliman, Raspall, Miquel, da Silva Duarte, Alberto José, Tuerlinckx, David, Virelizier, Jean-Louis, Fischer, Alain, Enright, Andrea, Bernhöft, Jutta, Cleary, Aileen M., Vermylen, Christiane, Rodriguez-Gallego, Carlos, Davies, Graham, Blütters-Sawatzki, Renate, Siegrist, Claire-Anne, Ehlayel, Mohammad S., Novelli, Vas, Haas, Walther H., Levy, Jacob, Freihorst, Joachim, Al-Hajjar, Sami, Nadal, David, de Moraes Vasconcelos, Dewton, Jeppsson, Olle, Kutukculer, Necil, Frecerova, Klara, Caragol, Isabel, Lammas, David, Kumararatne, Dinakantha S., Abel, Laurent, Casanova, Jean-Laurent
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193866/
https://www.ncbi.nlm.nih.gov/pubmed/12591909
http://dx.doi.org/10.1084/jem.20021769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193866/
https://www.ncbi.nlm.nih.gov/pubmed/12591909
http://dx.doi.org/10.1084/jem.20021769

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