Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists

Full activation of naive T cells requires both engagement of the T cell antigen receptor (TCR; signal 1) and costimulatory signaling by CD28 (signal 2). We previously identified two types of rat CD28-specific monoclonal antibodies (mAbs): “conventional,” TCR signaling–dependent costimulatory mAbs an...

Descripción completa

Detalles Bibliográficos
Autores principales: Lühder, Fred, Huang, Yun, Dennehy, Kevin M., Guntermann, Christine, Müller, Ingrid, Winkler, Erna, Kerkau, Thomas, Ikemizu, Shinji, Davis, Simon J., Hanke, Thomas, Hünig, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193880/
https://www.ncbi.nlm.nih.gov/pubmed/12707299
http://dx.doi.org/10.1084/jem.20021024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193880/
https://www.ncbi.nlm.nih.gov/pubmed/12707299
http://dx.doi.org/10.1084/jem.20021024

Ejemplares similares