The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit(+) T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus

In the thymus, several steps of proliferative expansion and selection coordinate the maturation of precursors into antigen-specific T cells. Here we identify the transcriptional repressor Gfi1 as an important regulator of this maturation process. Mice lacking Gfi1 show reduced thymic cellularity due...

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Detalles Bibliográficos
Autores principales: Yücel, Raif, Karsunky, Holger, Klein-Hitpass, Ludger, Möröy, Tarik
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193890/
https://www.ncbi.nlm.nih.gov/pubmed/12682108
http://dx.doi.org/10.1084/jem.20021417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193890/
https://www.ncbi.nlm.nih.gov/pubmed/12682108
http://dx.doi.org/10.1084/jem.20021417

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