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The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit(+) T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus
In the thymus, several steps of proliferative expansion and selection coordinate the maturation of precursors into antigen-specific T cells. Here we identify the transcriptional repressor Gfi1 as an important regulator of this maturation process. Mice lacking Gfi1 show reduced thymic cellularity due...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193890/ https://www.ncbi.nlm.nih.gov/pubmed/12682108 http://dx.doi.org/10.1084/jem.20021417 |