B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

In both humans and animals, immunoglobulin (Ig)G autoantibodies are less frequent but more pathogenic than IgM autoantibodies, suggesting that controls over Ig isotype switching are required to reinforce B cell self-tolerance. We have used gene targeting to produce mice in which hen egg lysozyme (HE...

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Detalles Bibliográficos
Autores principales: Phan, Tri Giang, Amesbury, Michelle, Gardam, Sandra, Crosbie, Jeffrey, Hasbold, Jhagvaral, Hodgkin, Philip D., Basten, Antony, Brink, Robert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193892/
https://www.ncbi.nlm.nih.gov/pubmed/12668643
http://dx.doi.org/10.1084/jem.20022144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193892/
https://www.ncbi.nlm.nih.gov/pubmed/12668643
http://dx.doi.org/10.1084/jem.20022144

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